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diagnosis hematology differential management algorithm causes classification leukemia mds myelodysplastic syndrome treatment approach arthritis calculation cell checklist chronic cll crisis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #Anemia #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... • Symptomatic anemia ... progress to MDS or acute ... Medicine @SCVMCMed #Aplastic
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Blood Loss • Acute ... Deficiency • Aplastic ... Anemia • Anemia ... Non-lmmune #Anemia
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Normal RBCs • Acute ... Spherocytes, RBC ... #Normocytic #Anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... marrow failure: Aplastic ... anemia, Marrow ... Index > 3: • Acute ... , Intrinsic RBC
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... treatment #hematology #oncology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... wide range of RBC ... High in acute blood ... Algorithm #Diagnosis #Workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... Pure red cell aplasia ... ’s lymphoma or acute ... #oncology #hematology
Checklist for Evaluation of New-Onset Delirium in the ICU Initial assessment - Vital signs, neuro exam
assessment - Vital signs ... /Mg/Phos - CBC ... tox/infectious workup ... Trauma - Acute ... Delirium #Evaluation #Workup
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
ischaemia. 2) Aplasia ... - Acute worsening ... of the baseline anaemia ... Crisis #Features #Signs
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