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diagnosis differential syndrome algorithm leukemia causes chronic classification cll lymphocytic mds myelodysplastic treatment apml approach arthritis bacilliformis bartonella blood calculation
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... progress to MDS or acute ... #management #treatment ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... #Anemia #oncology ... #hematology #diagnosis ... #management
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Blood Loss • Acute ... Deficiency • Aplastic ... Anemia • Anemia ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Normal RBCs • Acute ... Spherocytes, RBC ... Algorithm #Causes #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... #treatment #hematology ... #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... marrow failure: Aplastic ... Index > 3: • Acute ... , Intrinsic RBC ... Production #Index #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... High in acute blood ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... Pure red cell aplasia ... ’s lymphoma or acute ... #oncology #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Presentation: Subacute-Acute ... • Rare: DAH, acute ... , Anaphylaxis, Acute ... APML #diagnosis #management ... #hematology #oncology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... Presentation ​- Acute ... anorexia, ARDS ​• RBC ... severe hemolytic anemia ... Fever #diagnosis #management
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