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management hematology differential syndrome neurology causes symptoms rheumatology algorithm classification leukemia workup arthritis chronic cirrhosis cll fever hepatology infections infectiousdiseases
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Treatment: • Consider ... progress to MDS or acute ... #Anemia #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... F • 3 peaks: 1) ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Blood Loss • Acute ... Deficiency • Aplastic ... of Chronic Disease ... #Differential #Diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... #Management #treatment ... #hematology #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... Chronic kidney disease ... marrow failure: Aplastic ... Index > 3: • Acute ... #differential #diagnosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Female:Male 9:1 ... Pathophysiology ... Signs and Symptoms ... Diagnosis: • ... • AMA titer 1:
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... symptoms, or> 1 ... Renal Failure Treatment ... management #hematology #oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Infectious: • Acute ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... 5) Symptoms of anemia ... chemotherapy for low-risk disease ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
The underlying pathophysiology ... mechanism exist): 1) ... ischaemia. 2) Aplasia ... - Acute worsening ... Crisis #Features #Signs
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