24 results
hematology management causes differential syndrome algorithm classification leukemia chronic cll lymphocytic mds myelodysplastic pulmonary symptoms abscess acidosis apml approach bacilliformis
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Treatment: • Consider ... progress to MDS or acute ... #Anemia #diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Blood Loss • Acute ... Deficiency • Aplastic ... of Chronic Disease ... #Differential #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... transformation to acute ... #Management #treatment ... #hematology #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... Chronic kidney disease ... marrow failure: Aplastic ... Index > 3: • Acute ... #differential #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Infectious: • Acute ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... • Rare: DAH, acute ... Renal Failure Treatment ... management #hematology #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - ACS, AKI, acute ... >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... Syndrome #TLS #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... Pure red cell aplasia ... ’s lymphoma or acute ... #workup #oncology
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Sickle-cell disease ... The underlying pathophysiology ... ischaemia. 2) Aplasia ... - Acute worsening ... Crisis #Features #Signs
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