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Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Hypertriglyceridemia • Uremia ... turnover • Acute ... • Hemolytic anemia ... End-stage renal disease ... Increase #Decrease #Diagnosis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... , Liver diseases ... Malignant tumors, Acute ... coagulopathy (DIC) #RBC ... Morphology #Atlas #key #diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... - Differential Diagnosis ... Blood Loss • Acute ... Disease • Marrow ... #Differential #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... ARUPLabs #Hemolytic #Anemia ... #Differential #Diagnosis ... #Algorithm #workup
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Signs and Symptoms ... but elevated as disease ... Diagnosis: • ... , IgG4 related disease ... #workup #hepatology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Summary Clinical Signs ... demineralization) • Renal disease ... hypercalcemia) • Anemia ... plus one of: • Anemia ... #Management #oncology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... High in acute blood ... #Algorithm #Diagnosis ... #Workup #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... Chronic kidney disease ... Index > 3: • Acute ... , Intrinsic RBC ... #differential #diagnosis
Checklist for Evaluation of New-Onset Delirium in the ICU Initial assessment - Vital signs, neuro exam
assessment - Vital signs ... /Mg/Phos - CBC ... Trauma - Acute ... #MICU #CriticalCare ... #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Artifact (redo CBC ... Infectious: • Acute ... disorders • Celiac disease ... Iron deficiency anemia
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