27 results
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
convoluted tubule (PCT ... filtered Na+/K+/Cl ... Segments #Function #Pathophysiology ... #Tubules #Table ... #Pharmacology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Exogenous (KCL ... #differential #diagnosis ... #pathophysiology ... #pharmacology #
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
vary depending on treatment ... Ranges #Toxicology #Pharmacology ... #Diagnosis #Table
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Renal Failure Treatment ... fluid overload, PCC ... management #hematology #oncology
Orthopedic Essentials - Spinal Trauma and Spine Classification 
DENIS THREE COLUMN CONCEPT
Anterior column:
Middle column: PLL ... process fracture Stable ... deficit, still able ... Cauda equina Treatment ... #Orthopedics #diagnosis
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Lung Abscess Pathophysiology ... Clindamycin in case of PCN ... antibiotics once stable ... hemorrhage • Treatment ... shows a small, stable
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Complications and Treatment ... #SideEffects #Table ... #Diagnosis #Pharmacology ... #Oncology
Migraine Treatment Overview

 • What is a Migraine?
 • Pathophysiology
 • Common Migraine Triggers
 • Diagnosis
Migraine Treatment ... • Pathophysiology ... Migraine Triggers • Diagnosis ... • Non-Drug Treatment ... #management #pharmacology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... #Chemotherapy #Oncology ... #Interactions #Table ... #Pharmacology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... : 33% • Treatment ... : No • Treatment ... Reactions #hematology #diagnosis ... #comparison #table