74 results
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
glucose and amino acids ... reabsorption of organic acids ... including uric acid ... Segments #Function #Pathophysiology ... Tubules #Table #Pharmacology
Arachidonic acid pathway and drugs which affect it.

#Pharmacology #Pathophysiology #ArachidonicAcid #Pathways #COX #Prostaglandins #Prostacyclins #Leukotrienes #Synthesis

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Arachidonic acid ... #Pharmacology #Pathophysiology ... Text: Clinical Pharmacology
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Action of Bile Acid ... ↓ Hepatic Bile Acid ... ↑ Hepatic Bile Acid ... sequestration #pathophysiology ... #pharmacology #
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Lactulose → ↑ Lactic Acid ... , Acetic Acid → ... #Lactulose #pharmacology ... ammonia #hepatology #pathophysiology
Beta-Blockers in Cirrhosis
 • Pathophysiology
 • Indications:  Prevention of decompensation, Prevention of first variceal bleeding,
in Cirrhosis • Pathophysiology ... gastropathy • Dosing ... hepatology #management #pharmacology ... #indications #dosing
Diuretic Electrolyte Excretion Effects 
Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid
 - Thiazide Type
+, Mg2+, Ca2+, Cl ... -, HCO3-, Uric Acid ... electrolytes #effects #pharmacology
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Role of Uric Acid ... gout #uricacid #pathophysiology ... #pharmacology #
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Exogenous (KCL ... #hyperkalemia #differential ... #diagnosis #pathophysiology ... #pharmacology #
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
Uric Acid Homeostasis ... metabolized to uric acid ... converts uric acid ... Homeostasis #Gout #Pathophysiology ... #Pharmacology #
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Cystinuria - Amino acid ... syndrome - Na-K-2Cl ... barrtin (recruits Cl ... Thiazide-sensitive Na—Cl ... Nephrology #Diagnosis #Differential