31 results
Antibiotic Tissue Penetration

Blood Brain Barrier: Penicilins (IV), 3rd & 4th generation Cephalosporins (IV), Meropenem, TMP-SMX, Metronidazole,
Antibiotic Tissue ... Lungs: Most antibiotics ... inactivated by pulmonary ... Fluoroquinolones Poor Abscess ... #Penetration #pharmacology
Lung Abscess
Microbiology:
 • Polymicrobial 
 • Anaerobes (most common) 
Clinical: 
 • Indolent symptoms that evolve
Lung Abscess Microbiology ... , hemoptysis Treatment ... : • Empiric antibiotics ... meropenem) #Lung #Abscess ... #Diagnosis #Pulmonary
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Clindamycin in case of PCN ... Switch to oral antibiotics ... hemorrhage • Treatment ... treatment until ... #pulmonary #differential
COPD Exacerbations - Management
 • Identify Triggers
 • Assess Severity
 • Risk for Poor Outcomes
 •
Identify Triggers • Assess ... Outcomes • Initial Treatment ... bronchodilators - Antibiotic ... Exacerbation #Management #treatment ... #pulmonary
Chronic Obstructive Pulmonary Disease (COPD)
 • COPD Definition
 • Role of PFTs
 • COPD Classification and
Chronic Obstructive Pulmonary ... exacerbations requiring antibiotics ... (ABCD) - Assess ... #Obstructive #Pulmonary ... management #GOLD2022 #treatment
Causes of Antibiotic Failure - Differential Diagnosis Framework
Diagnosis:
 • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Causes of Antibiotic ... NMS, serotonin syndrome ... Immunocompromise Treatment ... Source control (abscess ... • Secondary to Treatment
Medical Treatment Algorithm for Chronic Obstructive Pulmonary Disease
Initial medical treatment of chronic obstructive pulmonary disease (COPD)
Medical Treatment ... Chronic Obstructive Pulmonary ... chronic obstructive pulmonary ... corticosteroids, antibiotics ... SABA #SAMA #ICS #Pharmacology
Cauda Equina Syndrome Overview

Cauda Equina Syndrome:
 • Prevalence: 1:33,000-100,000 ppl/yr
 • Incidence: 1.5-3.4 million ppl/yr
 •
Cauda Equina Syndrome ... 33,000-100,000 ppl ... 1.5-3.4 million ppl ... Spinal infection/abscess ... axial T1 and T2 Treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... Renal Failure Treatment ... fluid overload, PCC
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... Inhibitors of Na+K+2Cl ... Torsemide) • Acute pulmonary ... Tolvaptan) • Treatment ... Diuresis #Nephrology #Pharmacology