26 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
- Differential Diagnosis ... Table Warm AIHA ... Agglutinin Disease ... #Differential #Diagnosis ... #Table #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Disorientation, vertigo Diagnostic ... test, TempTest ... #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
, C3d ( +/- ) Cold ... agglutinin disease ... #antiglobulin #test ... Autoimmune #Hemolysis #hematology ... #diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Hemoglobinuria (PCH ... Test: Donath-Landsteiner ... test #cold # ... hemolytic #anemia #hematology ... #diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH ... Laboratory Tests ... #hematology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... syndrome Anti-Scl ... (TTG) - Celiac disease ... #diagnosis #table ... #rheumatology #
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
suspicion of severe disease ... and these should ... splenomegaly, abnormal neurology ... Rheumatology ... Peds #Pediatrics #Diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... practices that could ... K), H. pylori test ... (CVID, WAS), (neurologic ... Causes #Workup #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... should be obtained ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... SEROSITIS - RENAL - NEUROLOGIC ... reference range (or 2-fold ... Direct Coombs’ test ... #Rheumatology #