9 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... conditions - Sp-100, PML ... #differential #diagnosis ... #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... , others (RNP, aPL ... Anti-cardiolipin (aCl ... Anti-centromere, Scl ... Autoantibodies #Rheumatology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... conditions • Sp-100, PML ... #differential #diagnosis ... #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome in APML ... Incidence: common in APL ... fluid overload, PCC ... Differentiation #Syndrome #APML ... #hematology #oncology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
evaluation of the pattern ... box indicates all ... Areas of diagnostic ... decision for repeat testing ... Abnormal #Algorithm #Hepatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... should be obtained ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
adults in the west ... phenomenon CLL Diagnosis ... Transform to DLBCL, PML ... #workup #oncology ... #hematology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
vancomycin (if SSTI or port ... syndrome): - Hematologic ... : - Seen with AML ... (~20 %) and APL ... #HemeOnc #Diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Pinpoint-sized red spots ... transformation to AML ... progression to AML ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology