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ana antibody antinuclear differential nuclear patterns workup arthritis associations autoantibodies chronic cll cytoplasmic differentiation disease emergencies hemeonc laboratory leukemia lymphocytic
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... , others (RNP, aPL ... Anti-cardiolipin (aCl ... Anti-centromere, Scl ... Autoantibodies #Rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... conditions - Sp-100, PML ... #differential #diagnosis ... #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Incidence: common in APL ... fluid overload, PCC ... Differentiation #Syndrome #APML ... #hematology #oncology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... should be obtained ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... conditions • Sp-100, PML ... #differential #diagnosis ... #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... phenomenon CLL Diagnosis ... Transform to DLBCL, PML ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Pinpoint-sized red spots ... transformation to AML ... progression to AML ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
vancomycin (if SSTI or port ... syndrome): - Hematologic ... : - Seen with AML ... (~20 %) and APL ... #HemeOnc #Diagnosis
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