15 results
Acid-Base Disorders - Differential Diagnosis Algorithm
Acidemia (pH < 7.35)
 • Metabolic Acidosis (HCO3 < 24mmol/L) CO2
Acid-Base Disorders ... Differential Diagnosis Algorithm ... Respiratory Acidosis (pCO2 ... Respiratory Alkalosis (pCO2 ... Differential #Diagnosis #Algorithm
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
+ (↑ pH) • ↓ PCO2 ... tissue): • ↑ H+ (Acid ... ) • ↑ PCO2 • ... Dissociation #Curve #pathophysiology
Acid Base and Blood Gas Analysis
1. pH - What’s the primary disturbance?
2. pCO2 - What’s the
Acid Base and Blood ... 2. pCO2 - What’s ... the pCO2? ... Medications, Central, ↑ CO2 ... acidbase #workup #algorithm
Arachidonic acid pathway and drugs which affect it.

#Pharmacology #Pathophysiology #ArachidonicAcid #Pathways #COX #Prostaglandins #Prostacyclins #Leukotrienes #Synthesis

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Arachidonic acid ... #Pharmacology #Pathophysiology ... Text: Clinical Pharmacology
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Action of Bile Acid ... ↓ Hepatic Bile Acid ... ↑ Hepatic Bile Acid ... sequestration #pathophysiology ... #pharmacology #
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Lactulose → ↑ Lactic Acid ... , Acetic Acid → ... #Lactulose #pharmacology ... ammonia #hepatology #pathophysiology
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
Uric Acid Homeostasis ... metabolized to uric acid ... converts uric acid ... Homeostasis #Gout #Pathophysiology ... #Pharmacology #
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Role of Uric Acid ... gout #uricacid #pathophysiology ... #pharmacology #
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
glucose and amino acids ... reabsorption of organic acids ... including uric acid ... Segments #Function #Pathophysiology ... Tubules #Table #Pharmacology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... : • Low CO2 = ... CPP) • High CO2 ... and via lactic acid ... Pressure #ICP #Pathophysiology