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diagnosis anemia workup analysis anemias blood causes clinical hemolysis interpretation maha management mds microangiopathic microangiopathy myelodysplasia myelodysplastic oncology pancytopenia pathology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Reticulocytes • Abnormal peripheral ... smear Immune-mediated ... Matthew Ho, MD PhD ... #hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Smear Analysis ... #Blood #Smear # ... Analysis #hematology ... #microscopy #interpretation
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
12-13 g/dL, • ANC ... BMP, uric acid, peripheral ... smear, reticulocyte ... ↑ Destruction (hemolysis ... #hematology #workup
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... smear changes are ... #anemia #Hematology ... #Pathology #Smear ... #Microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
- Differential ... Diagnosis Algorithm ... Hereditary: • Peripheral ... blood smear + DAT ... #Anemia #Differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Diagnosis Algorithm ... Peripheral Smear ... blood loss, Acute hemolysis ... Matthew Ho, MD PhD
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
and Management Algorithm ... Reticulocytes, smear ... MAHA likely: • Smear ... Matthew Ho, MD PhD ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal ... #Differential # ... Diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hemorrhage and hemolysis ... the range of Peripheral ... blood smear - Shows ... WBC count and differential ... Diagnosis #Workup #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... Smear: • Dysplastic ... blood count with differential ... smear • Bone marrow ... Syndromes #diagnosis #hematology
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