19 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... - Differential ... Reticulocytes • Abnormal peripheral ... smear Immune-mediated ... Matthew Ho, MD PhD
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing in Hemolytic ... Extravascular Hemolysis ... bilirubin LDH Peripheral ... smear Haptoglobin ... #hematology #hemolysis
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... blood smear + DAT ... Immune mediated hemolysis ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Smear Analysis ... Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... #Blood #Smear # ... Analysis #hematology #microscopy
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
microangiopathic hemolytic ... and laboratory diagnosis ... Microangiopathic hemolytic ... microangiopathic #hemolytic ... #Microscopy
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... C3d • Blood smear ... : Differential → ... Antibody #Autoimmune #Hemolytic
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Diagnosis Algorithm ... BMP, uric acid, peripheral ... smear, reticulocyte ... ↑ Destruction (hemolysis ... Matthew Ho, MD PhD
Streptobacillus moniliformis on peripheral smear and culture microscopy
 - blood culture; patient w/ outdoor exposure
 -
moniliformis on peripheral ... smear and culture ... culture; patient ... Rich Davis, PhD, ... moniliformis #blood #smear
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal ... Urobilinogen #Hemolysis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hemorrhage and hemolysis ... intravascular hemolysis ... blood smear - Shows ... out an immune hemolytic ... the severity of hemolysis