36 results
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
- IFE - FLC ... Testing #Protein #Diagnosis ... MGUS #SPEP #IFE #FLC ... #Nephrology #Laboratory ... #Comparison #Table
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
, PBC/SjS OS ... -7, PL-12, MDA5, ... body-like: - Neurologic ... #differential #diagnosis ... #rheumatology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... SaltWasting #SIADH #Pathophysiology ... #diagnosis #nephrology ... #hyponatremia #comparison
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
and Management ... ♀, ↑Age, ESRD Pathophysiology ... heparin-PF4 complex → plt ... hypercoagulable state and plt ... #Hematology #HemeOnc
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... Erythematosus #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis ... #management #treatment
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... Cr, ↓Glucose, ↓PLT ... ) Differential Diagnosis ... obstetrics #obgyn #diagnosis ... #management #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Auto-amplification loop Diagnosis ... Cytopenia +++ (Plt ... #management #treatment ... #summary #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... for decreased PLT ... (CVID, WAS), (neurologic ... #Differential #Diagnosis ... Causes #Workup #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... opacities • Diagnosis ... • Differential Diagnosis ... fluid overload, PCC ... #management #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology ... #diagnosis #comparison