14 results
hematology diagnosis management differential algorithm leukemia mds myelodysplastic syndrome workup apml calculation causes chronic classification cll differentiation gammopathy gap globulin
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... cytopenias (usually anemia ... transformation to acute ... #hematology #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Treatment: • Consider ... stem cell transplant ... progress to MDS or acute ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... • ↓ WBC • ↓ PLT ... anemia Treatment ... #Anemia #oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
• Marrow Aplasia ... Normal RBCs • Acute ... RBCs - Sickle Cells ... , Target Cells ... Inflammation • Cancer
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... • Neutropenia, anemia ... aplasia • ITP ... microglobulin Treatment ... ’s lymphoma or acute
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Acute leukemias ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Leukemia #Hematology ... #Oncology #Diagnosis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
marrow failure: Aplastic ... infiltration (e.g. cancer ... Index > 3: • Acute ... defects (e.g. sickle cell ... Production #Index #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... factor (GCSF) treatments ... marrow studies Treatment ... Syndromes #diagnosis #hematology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... • Induce blast cell ... fluid overload, PCC ... #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
the hematologic cancer ... No evidence of anemia ... insufficiency, Anemia ... #Significance #hematology ... #diagnosis #oncology
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