22 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Syndrome (SS), ... (SLE), Systemic ... : Lupus (SLE), Systemic ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... Treatment: • ... diagnosis #rheumatology ... #management
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
, autoimmune hepatitis ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... La) - Sjogren's syndrome ... diagnosis #table #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
accompanies other autoimmune ... diseases • In ... biliary cirrhosis (PBC ... lupus erythematosus ... (SLE) Signs /
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... arthritis, adult-onset Still ... rheumatologic diseases ... Antiribosomal P, APLA, PAC ... #Systemic #Lupus
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... Demyelinating Syndrome ... Cerebrovascular Disease ... #rheumatology # ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... life-threatening • Treatment ... : Chronic disease ... #lupus #Systemic ... #Summary #rheumatology
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Disease (AOSD) ... likely conditions (autoimmune ... episode (30%) Systemic ... #rheumatology #diagnosis ... #management #treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Adult-onset Still ... diseaseSystemic ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... #Diagnosis #Management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... Usual therapeutic management ... : Chronic disease ... #table #rheumatology ... #diagnosis #management