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differential testing antinuclear cytoplasmic hematology nuclear anemia antibodies aplastic apml associations autoantibodies autoimmune challenges comparison criticalcare differentiation diseases fluid myopathy
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... : - SSc, PBC/ ... , PBC/SSc OS, PBC ... #differential #diagnosis ... #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... : • SSc, PBC/SSc ... : • PBC, DM, other ... #differential #diagnosis ... #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
• PBC, SSc, PBC ... /SSc OS, PBC/SjS ... ARUPConsult @ARUPLabs #ANA ... #differential #diagnosis ... #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Disease Associations ANA ... biliary cirrhosis (PBC ... disease Endomyseal antibody ... Associations #diseases #diagnosis ... #table #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
opacities • Diagnosis ... • Differential Diagnosis ... fluid overload, PCC ... #management #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
petechiae Causes ... • ↓ WBC • ↓ PLT ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Fluid Responsiveness and Fluid Tolerance Testing - OnePager Summary Fluid resuscitation can be beneficial when required or
measurement of CO via a PAC ... cardiac output causes ... lung US pattern ... Tolerance #testing #diagnosis ... comparison #challenges #management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... pattern of muscle ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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