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diagnosis oncology syndrome lupus differential leukemia ana antibody antinuclear classification druginduced erythematosus nuclear patterns summary systemic testing acidosis activation acute
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
I see all of these ... features in most cases ... promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - PBC ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... , RA, PBC, UCTD ... differential #diagnosis #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Renal Failure Treatment ... fluid overload, PCC ... #diagnosis #management ... #hematology #oncology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... 40, F:M 9:1 • Clinical ... Positive in 60-80% of cases ... life-threatening • Treatment ... #Summary #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
: Blast crises ... Leukocyte count ↑ PLT ... Significant ↓ PLT ... count • ↓Hg & PLT ... #Leukemia #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... autoantibodies that will cause ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
pattern: • SjS, SLE ... pattern: • SSc, PBC ... dots pattern: • PBC ... conditions • Sp-100, PML ... differential #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... Autoimmune diseases: SLE ... Treatment: • ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
heparin-PF4 complex → plt ... Diagnosis: • Clinical ... Confirmatory test ↑Se ... non-heparin A/C if clinical ... #Treatment #Hematology
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