17 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
: - Thrombocytopenia ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... child * Severe cases ... @Bloodman #Thrombocytopenia ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... child * Severe cases ... Bloodman #Pregnancy #Thrombocytopenia ... AFLP #obstetrics #hematology ... #diagnosis #table
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE) Clinical ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... Thromboembolism (7%) • CNS ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
nervous system (CNS ... SJIA], systemic lupus ... leukopenia, anemia, and thrombocytopenia ... Diagnosis #Management #Hematology ... #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Discontinuation of causal ... 40, F:M 9:1 • Clinical ... sle #comparison #table ... #rheumatology #
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
considered in all cases ... Heparin-induced thrombocytopenia ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... count ↑ PLT • ↑ PBS ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology