PNS hematology causes edema hepatology hemolytic cirrhosis diagnosis classification liver hemolysis

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

for Hemolysis - ... Intravascular Hemolysis ... Microangiopathic hemolytic ... purpura (TTP), Hemolytic ... #hematology #anemia

Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production:
• Increased Reticulocytosis/polychromasia
• Erythroid

Hemolysis - Diagnostic ... Algorithm and Causes ... haptogbbulin #Hemolysis ... #Hemolytic #Anemia ... #Workup #Hematology

Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
-

Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... immune-complex hemolytic ... #Hematology

Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
• Membrane
• Internal
- Hemoglobin

Causes of Hemolytic ... - Differential Diagnosis ... Sophia_Hayes_MD #Hemolytic ... #Differential #Diagnosis ... #Causes #hematology

Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
• Enzyme deficiencies ex. G6PD, pyruvate kinase
• Hemoglobinopathies

for Hemolytic Anemia ... : • Liver disease ... udaygulati #Hemolytic ... #causes #classification ... #hematology

Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80

Causes of Anemia ... - Differential Diagnosis ... • Bleeding • Hemolysis ... #Anemia #MCV #Classification ... #Hematology

Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
- Decreased/NormaI

Causes of Anemia ... - Differential Diagnosis ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... #Hematology

Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
• Thalassemia

-100): • Non-hemolytic ... anemia, CKD • Hemolytic ... PK, HbC, HbSS, PNH ... Non-megaloblastic: Liver ... #hematology

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... - Differential Diagnosis ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... Algorithm #workup #hematology

Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
• Bacterial
• Viral (EBV)
• Parasitic
• Fungal
Congestive

- Differential Diagnosis ... Congestive • Cirrhosis ... Serum Sickness Hemolytic ... #Differential #Diagnosis ... #Hematology

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