22 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... activity • ↓ LAP ... AML: Blast crises ... #Hematology #Oncology ... #Diagnosis
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm
 • Reactive (Inflammatory / Infectious)
 •
Causes of Diffuse ... - Differential Diagnosis ... • Neoplastic (Leukemia ... Lymphadenopathy #LAD ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... - Differential Diagnosis ... Lymphadenopathy #LAD ... #Algorithm #Causes ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Diagnosis: • ... microglobulin Treatment ... leukemia #CLL ... #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... transformation to acute leukemia ... Allogeneic stem cell ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Symptomatic anemia Diagnosis ... Consider stem cell ... to MDS or acute leukemia ... • Associated PNH ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
(CLL) - Summary ... minimal tumor burden Diagnosis ... uw_IMresidency #CLL ... #oncology #hematology ... #hemeonc #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... hemoglobinuria (PNH ... ) (e.g. lupus, CLL ... #hematology #anemia
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
without other cause ... with pulmonary edema ... Transfusion #Reactions #hematology ... #diagnosis #comparison ... #table
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
promyelocytic leukemia ... Treat primary cause ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology