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diagnosis rheumatology treatment syndrome sle cardiology dermatology erythematosus table differential disease systemic comparison druginduced hcq heartfailure hydroxychloroquine intravascular medications nephrology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology ... cerebritis #diagnosis #management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
suspected) • In case ... • Special cases ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... #Summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... lower extremity edema ... proteinuria, dependent edema ... • May involve PNS ... vein thrombosis Hematologic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... Extravascular #Causes ... differential #diagnosis #hematology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... rosacea) 3) Limb oedema ... pericarditis » is...lupus ... Lupusreference #lupus ... erythematosus #rheumatology
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
Diagnosis and Management ... no respiratory cause ... like DKA, sepsis, PNA ... Diaphoresis, Pulmonary edema ... Level: 150mg/kg Management
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
shift • Saline Causes ... • Saline May Cause ... • Increases Edema ... volume - increased edema ... #comparison #pharmacology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... rare with ~100 cases ... Risks #Benefits #Lupus ... #pharmacology # ... #sideeffects #rheumatology
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