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diagnosis rheumatology algorithm treatment nephrology hemolytic syndrome classification pulmonary cardiology infections infectiousdiseases intravascular lesions oncology syndromes workup acute aids autoimmune
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... #differential # ... diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... • PCH • PNH ... anemia • ... #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
AIHA • Anemia ... • Blood smear: Differential ... 2) LOOK FOR a cause ... #management #treatment ... #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... • Bleeding • Hemolysis ... Classification #Differential ... #Hematology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
CNS Ring-Enhancing ... + toxo IgG • CNS ... 30% present w/ CNS ... @AnnKumfer #CNS ... #radiology #neurology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... platelet decrease - PNH ... #Anemia #Differential ... Algorithm #workup #hematology
CNS Ring-Enhancing Lesions - Differential Diagnosis • Infections: Cerebral abscess (bacterial, fungal, parasitic), Neurocysticercosis, Tuberculoma, Cerebral
CNS Ring-Enhancing ... multiforme, Primary CNS ... Demyelinating Disease ... StanfordChiefs #CNS ... #radiology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... , CKD • Hemolytic ... PK, HbC, HbSS, PNH ... Non-megaloblastic: Liver disease ... #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... #Anemia #Differential ... classification #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... , sickle cell disease ... anemia, PNH, immune ... Periodic paralyses CNS ... Dehydrogenase #Elevated #differential
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