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diagnosis differential anemia extravascular hemolytic intravascular thrombocytosis workup blood dermatology enlarged erythrocytosis increased markers neutrophilia neutrophils nonpalpable palpable purpura secondary
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... Differential Diagnosis Algorithm ... • Metabolic disorders ... myelogenous leukemia • Polycythemia ... #Causes #Hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Differential Diagnosis Algorithm ... Lymphoid (ALL) - PAS ... bcr-able (-) - Polycythemia ... #hematology #Markers ... Differential #Diagnosis #Algorithm
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Differential Diagnosis Algorithm ... Myeloproliferative disorders ... (eg. polycythemia ... Serum Sickness Hemolytic ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Differential Diagnosis Algorithm ... thrombocytosis • Polycythemia ... • Rheumatic disorders ... #Causes #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Differential Diagnosis Algorithm ... • PCH • PNH ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... hemoglobinuria (PNH ... lymphoproliferative disorders ... Extravascular #Causes ... differential #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... thrombocythemia (ET) • Polycythemia ... #hematology #secondary
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Differential Diagnosis Algorithm ... Splenomegaly, Increased PMNs ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
, or other causes ... DIC/TTP/HUS - Hemolytic ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... platelet decrease - PNH ... Consider RBC membrane disorder ... Differential #Diagnosis #Algorithm ... #workup #hematology
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