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diagnosis management syndrome chronic hemeonc lymphocytic mds myelodysplastic acute algorithm all anemia aplastic cancer cardiomyopathy cardiotoxicity chemotherapy classification dermatology emergencies
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... -> AML: Blast crises ... ) CLL Symptoms: ... Transformation: • Complication ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... kinase (BTK) Complications ... • GI complications ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... • Risks: infection ... transformation to acute leukemia ... Allogeneic stem cell ... #hematology #oncology
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
for Standard-Risk ... Lymphoblastic Leukemia ... Consolidation & CNS ... Cytarabine #ALL ... #oncology #pediatrics
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... thrombocytopenia Complications ... chemotherapy for low-risk ... uw_IMresidency #CLL ... #oncology #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Consider stem cell ... neutropenic fever) Complications ... to MDS or acute leukemia ... • Associated PNH ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
carries a variable risk ... Leukemia • Idiopathic ... and reducing the risk ... Syndromes #diagnosis #hematology ... #oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
general feeling of ill ... Causes: - Idiopathic ... , breast CA - Hematologic ... Treatment: - Systemic ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... mg/dL or > 25 % rise ... Treat underlying cause ... Usually myeloid leukemias ... ± tocilizumab; call
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity Anthracyclines cause cardiomyopathy: ✖ Reduction in left ventricular ejection fraction
cause cardiomyopathy ... HER2 agents cause ... ) and initiate treatment ... Cardiotoxicity #cardiology ... #oncology #pharmacology
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