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diagnosis management differential oncology algorithm sle syndrome erythematosus cll hemeonc leukemia lymphocytic myelodysplastic summary activation atopic atopy autoimmune cerebritis classification
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... life-threatening • Treatment ... • Evolution: Chronic ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
of Systemic Lupus ... autoantibodies that will cause ... Puncture, EEG Treatment ... Maheswaranathan, MD ... #rheumatology #
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Reactive: - Systemic ... Lupus Erythematosus ... Age > 50 • Chronic ... #Hematology #Oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Rebound effect from treatment ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Causes of Isolated ... Idiopathic - Chronic ... Destruction • Systemic ... Lupus Erythematosus ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... • Risks: infection ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... #hematology #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... (CNS) dysfunction ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... months to years) Systemic ... • Evolution: Chronic ... comparison #table #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... Infection exposure (l MD ... SOAP) - Risks ... or if a primary hematologic ... #Workup #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • May involve PNS ... Thrombosis highest risk ... : • Chronic B-cell ... #Diagnosis #Rheumatology
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