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diagnosis differential algorithm anemia hemolytic management deficiency extravascular oncology polycythemia agglutinin atlas classification coagulation cold dic disease disseminated dyspnea emergencies
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... elliptocytosis - RBC ... • PCH • PNH ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... hemoglobinuria (PNH ... • Intrinsic RBC ... #Hemolytic #Intravascular ... #diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron ... #Hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
loss: Intravascular ... (not extravascular ... ) hemolysis, Intensive ... athletic training, Pulmonary ... Algorithm #ferritin #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... • Microcytic - Iron-deficiency ... PD deficiency, Pulmonary ... , Disseminated intravascular ... #differential #hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
: CBC with diff, ... LDH, ESR, CRP, iron ... ↑ Destruction (hemolysis ... Diagnosis #Algorithm #hematology ... #workup
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
acute blood loss, hemolysis ... erythropoietin (EPO), iron ... substrate (e.g. iron ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
platelet decrease - PNH ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... Diagnosis #Algorithm #workup ... #hematology #testing
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... loss: Intravascular ... hemolysis, (PNH ... athletic training, Pulmonary ... Differential #Diagnosis #Causes
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
reflection of intravascular ... schistocytes, nucleated RBCs ... from ischemia WBC ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
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