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diagnosis hematology differential algorithm causes management workup hemolytic oncology cirrhosis microscopy pathophysiology smear treatment clinical pbc primary biliary laboratory liver
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... RBC) Morphology ... Microcytic RBC: ... , McLeod blood group ... Target Cell RBC
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Decreased RBC ... Disease • Marrow ... Thalassemia • RBC ... Disorder • RBC
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Normocytic #Anemia ... Algorithm #Causes #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... • Hemolytic anemia ... Dilutional Effect • RBC
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... , Drugs, Liver Disease ... 3) Internal (RBC ... Defects: Sickle cell anemia ... - Peripheral Blood
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... , Liver diseases ... coagulopathy (DIC) #RBC ... #differential #hematology
Pathophysiology of Hemolytic Anemia - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects) -
Pathophysiology of Hemolytic Anemia ... - Defects in RBC ... - Defects in RBC ... Pathophysiology #Hemolytic #Anemia ... #hematology
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Pathologic Red Blood ... Cell (RBC) Morphologies ... and Associated Diseases ... cell, Other RBC ... Howell-Jolly bodies #RBC
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... , Hemolytic anemia ... : Hemoglobin H disease ... Sickle cell, MDS #RBC ... Bodies #diagnosis #hematology
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