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rheumatology differential causes lupus systemic ana antinuclear classification algorithm autoantibodies management table workup abnormal aptt coagulation diseases druginduced patterns prolonged
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
disease (MCTD), Drug-induced ... (SLE), Sjogren's ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Systemic lupus erythematosus ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... involvement 3% SLE-Related ... Auto-Antibodies ... Lupus Mimickers: Drug-induced ... Lupusreference #SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... extremities Drug ... 1, SCL-70, RNP antibodies ... • Antihistone: Drug ... #Diagnosis #Rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-histone - Drug-induced ... Dermatomyositis Anti-LKM (liver ... Associations #diseases #diagnosis ... #table #rheumatology ... #antibodies
Lupus Classification Spontaneous Lupus - Cutaneous Lupus Erythematosus (CLE) - Systemic Lupus Erythematosus Drug-Induced Lupus - Drug-Induced
Drug-Induced ... CLE (SCLE-DIL) ... - Drug-Induced ... #rheumatology # ... diagnosis #differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... methotrexate) • Drugs ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... Algorithm #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Blood Smear • Drugs ... B12 - Anti-IF Antibodies ... B12 - Anti-IF Antibodies ... Algorithm #Causes #Hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Systemic lupus erythematosus ... Anti-histone (in drug-induced ... SLE) • Systemic ... #diagnosis #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Systemic Lupus Erythematosus ... pericarditis • Hematologic ... Highly specific antibodies ... Classification #Criteria #SLE ... #diagnosis #rheumatology
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