23 results
Treatment of Non-hepatitis C virus Cryoglobulinemia Vasculitis - French Vasculitis Study Group

MONOCLONAL CRYOGLOBULINEMIA (TYPE 1) 
IgM
Treatment of Non-hepatitis ... Vasculitis - French ... Vasculitis Study ... /or refractory disease ... #Rheumatology #
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Vasculitis 1 ... arterioles) MONOCLONAL ... Hyperviscosity syndrome ... arthritis • Renal ... #Rheumatology #
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
vasculitis - Diagnosis ... with purpura - Renal ... neuropathy Treatment ... with refractory disease ... #Vasculitis #Rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
capillary leak syndrome ... • Cryoglobulinemia ... Renal-centered ... Ig deposition disease ... #Diagnosis #hematology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... - Differential ... - Anti-GBM Disease ... Complement Levels: SLE, Cryoglobulinemic ... #Differential #
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
drug eruptions, paraneoplastic ... Urticarial/LCV) - Cryoglobulinemic ... : • Behcet Disease ... • Cogan syndrome ... #dermatology #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
syndrome in 80% ... • Autoimmune diseases ... Cryoglobulins: - Single monoclonal ... - Composed of monoclonal ... classification #rheumatology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... , Cryoglobulinemia ... #Syndrome #differential
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... (Cryoglobulinemic ... Sneddon-Wilkinson disease ... vascular beds-renal ... #Monoclonal #Differential
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... pulmonary and renal ... ANCA +MPO) • Cryoglobulinemic ... • Urinalysis (Renal ... #rheumatology #