8 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Extravascular ... • MAHA (TTP, DIC ... #Hemolysis #Intravascular ... #Extravascular ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
coagulation (DIC ... hemoglobinuria (PNH) Extravascular ... G6PD deficiency) ... #Extravascular ... #diagnosis #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Anemia - Differential ... • Iron loss: Intravascular ... (not extravascular ... #Anemia #Differential ... #ferritin #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... , Disseminated intravascular ... coagulopathy (DIC ... key #diagnosis #differential ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • DIC ... #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... IVIG infusion Intravascular ... MAHA: TTP, HUS, DIC ... Diagnosis #causes #classification ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... organ damage Clinical ... thrombopoietin deficiency ... #Disseminated #Intravascular ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Clinical Presentation ... younger pts) Differential ... the RBCs causing intravascular ... #hematology #diagnosis