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rheumatology differential erythematosus causes systemic classification management oncology purpura signs symptoms testing activation algorithm arthritis autoantibodies bruising chronic cll dermatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... (<1000/MM3) - THROMBOCYTOPENIA ... anemia #Diagnosis ... #Rheumatology # ... SLE #Lupus #Erythematosus
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... ): SS, SC, SE, Sβ ... Schistocytes, thrombocytopenia ... #workup #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... involvement 3% SLE-Related ... Lupusreference #SLE
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
pain (20%) Renal disease ... ) Blood (75%): Anemia ... Leucopenia/lymphopenia, Thrombocytopenia ... #Lupus #SLE #systemic ... signs #symptoms #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
pericarditis • Hematologic ... domain: Leukopenia, Thrombocytopenia ... , Autoimmune hemolysis ... #SLE #Systemic ... #diagnosis #rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
) - SLE ( ... systemic lupus erythematosus ... Congenital heart disease ... #Causes #peds #pediatrics ... #diagnosis #differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... - CTD (SLE) ... #hematology #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... hallmark for the disease ... result in severe anemia ... anemia Indirect ... #Workup #Hematology
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