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leukemia syndrome algorithm causes cll lymphocytic mds myelodysplastic thrombocytosis activation aplastic apml arteritis classification cvid differentiation gca giantcell hemeonc hodgkins
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelofibrosis Infectious ... effect following treatment ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... : Chronic infections ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Complications: 1) Infection ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... risk-stratification • Risks: infection ... only curative treatment ... #Management #treatment ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... specifically immune thrombocytopenia ... autoimmune hemolytic anemia ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
/fevers • Thrombocytopenia ... Idiopathic • Infections ... Treatment: ... #oncology #hematology ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... initiation • Differential ... Diagnosis: Infection ... #management #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... • Neutropenia, anemia ... , thrombocytopenia ... #workup #oncology ... #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Infant/child: - Infection-common ... Megaloblastic anemia-rare ... ambulatory patients - Infections-common ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... - infiltrates (anemia ... , thrombocytopenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
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