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algorithm syndrome causes oncology anemia classification dermatology gastroenterology hemophagocytic lymphohistiocytosis blood chronic disorders hemolytic hepatitis hodgkins lymphoma mcv platelet product
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... lymph node, or liver ... agent are the main ... #management #treatment ... #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diagnosis Congenital ... Diseases: • GATA2 ... erythematosus • HLH ... deficiency Infections ... #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Myelofibrosis Infectious ... disorders • Celiac disease ... effect following treatment ... #Causes #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... Renal Disease, Liver ... Inflammation, Chronic Infection ... #Causes #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
neurology, back pain ... Haematology - ... Rheumatology ... Pathway #Child #Peds ... #Pediatrics #Diagnosis
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Supportive with treatment ... Hepatobiliary #hepatology ... #hepatitis #differential ... #diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... disease, liver ... Coagulation Failure Infections ... Failure #Cirrhosis #Hepatology ... #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
associated with infection ... or autoimmune disease ... for refractory disease ... #Treatment #management ... #hematology
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