22 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... , Vasculitides, ... : Chronic infections ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... , bleeding, infections ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... : • Recurrent infections ... neutropenia • Mucosal bleeding ... #diagnosis #management ... #treatment #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Diagnosis Framework ... the total white blood ... Disorders: • Chronic ... Colitis and Crohn’s Disease ... #hematology #basophils
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
AIHA, Transfusion reactions ... Internal (RBC) - Infections ... anemia, Thalassemias ... - Peripheral Blood ... #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
kidney disease, ... (e.g. cancer, infection ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... younger pts) Differential ... sensitize red blood ... chills, flank pain ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
weeks without infection ... Physical Exam/Signs ... cells can indicate disease ... • Neutropenia, anemia ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... Complications: 1) Infection ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... procedures - Infection ... plateletcount), peripheral blood ... changes), high MCV anemia ... #Workup #hematology