23 results
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm
 • Reactive (Inflammatory / Infectious)
 •
Causes of Diffuse ... • Neoplastic (Leukemia ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Neoplastic: - Leukemia ... Lymphoblastic Leukemia ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... erythematosus (SLE ... scleroderma • Peripheral ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blasts in the peripheral ... -> AML: Blast crises ... maturation • (Peripheral ... • ↓Hg & PLT • Peripheral ... #Hematology #Oncology
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia ... I see all of these ... features in most cases ... promyelocytic #leukemia ... APML #Pathology #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Leukemia, Tumour ... Autoimmune • ITP • SLE ... Diagnosis #Algorithm #Causes ... #Hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... seen in 30—70% of cases ... Jcortesizaguirr #ANA #Antinuclear ... antibodies #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Scl70 (in some cases ... Scl-70 (in some cases ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... non-Hodgkin lymphoma SLL ... cytometry • Peripheral ... diagnosis #workup #oncology ... #hematology