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diagnosis differential erythematosus classification dermatology management symptoms antibodies antibody antinuclear aortitis autoantibodies autoimmune chronic cll comparison cryoglobulinemia cryoglobulins druginduced hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... lupus erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... #diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases ... , and SLE) • Urinalysis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... : - ANA > ... Evolution: Chronic disease ... #lupus #Systemic
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... (lupus, RA, Sjogren's ... deficiency Work ... cryoglobulins • Skin ... #Petechiae #Rash
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... (SLE), Sarcoidosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... Serositis Labs: • ANA ... antibodies • (-) ANA ... #Systemic #Lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... , Vasculitis, Purpura ... pain (20%) Renal disease ... #SLE #systemic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
: - ANA > ... months to years) Systemic ... : - ANA > ... Evolution: Chronic disease ... #table #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... #Systemic #Lupus
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
rheumatic diseases ... disease, drug reactions ... most important diseases ... (GRANULOMATOUS DISEASE ... HBV Kawasaki Disease
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