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differential oncology algorithm treatment workup hemolytic hemophagocytic lymphohistiocytosis pancytopenia causes chronic hemolysis hodgkins leukemia lymphocytic lymphoma activation agglutinin antinxp2 antinxp2dm
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Megakaryopoiesis • Aplastic Anemia ... ITP • SLE • CLL ... • anti-HLA antibodies ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... erythematosus • HLH ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Autoimmune Mediated ... HLH syndrome 5. ... Acquired Aplastic Anemia ... Metastatic Disease ... #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Autoimmune Mediated ... HLH syndrome 5 ... Acquired Aplastic Anemia ... Metastatic Disease ... #Algorithm #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
iron deficiency anemia ... spherocytosis, Autoimmune ... : Cold autoimmune ... #differential #diagnosis ... #hematology #microscopy
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... ) (e.g. lupus, CLL ... #differential #diagnosis ... #hematology #anemia
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
with infection or autoimmune ... disease, treatment ... for refractory disease ... #Treatment #management ... #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Diagnosis: • Pancytopenia ... Consider stem cell ... #diagnosis #management ... #treatment #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
EBV infection, Autoimmune ... Pylori) - Autoimmune ... translocation • Types: Classification ... Differential Diagnosis ... #differential #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... : HLH signs and ... Low or absent NK cell ... #management #treatment ... #hematology
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