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differential causes oncology chronic hemeonc lymphocytic anemia arterial bleeding bruising classification dic disseminated extravascular hemolysis hemolytic heparin hit induced lymphomas
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
- Differential Diagnosis ... Algorithm Thrombocytopenia ... Sequestration Disordered ... • Disseminated Intravascular ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
coagulation (DIC ... microangiopathy: Thrombotic thrombocytopenic ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... #hematology #anemia
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Chronic Myelogenous Leukemia ... • Rheumatic disorders ... • Celiac disease ... effect following treatment ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... , coagulation disorders ... #hematology #rheumatology ... #nonpalpable #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cells can indicate disease ... lymphoproliferative disorders ... microglobulin Treatment ... #oncology #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... protein C and S Pathophysiology ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... Testosterone - Coumadin skin ... - Disseminated intravascular ... coagulation and ... #hematology #differential
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... in adults • Disorder ... chemotherapy for low-risk disease ... #oncology #hematology ... #management
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... Treated Like Acute Leukemias ... Classification #pathophysiology ... #Hematology #Diagnosis
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
arterial thrombosis, skin ... ♀, ↑Age, ESRD Pathophysiology ... D/c all heparin ... #Diagnosis #Management ... #Treatment #Hematology
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