20 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... Aldosterone Release: ACE ... Pathophysiology #Pharmacology ... #Impaired #Potassium
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... Hypertensive: • High Al ... aldosteronism • High Al ... #Hypokalemia #Differential ... #causes #low #potassium
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
with excreting potassium ... Antagonists), all ... will increase potassium ... , just like all ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
Potassium Channel Blockers - Medications
1. Cardiovascular Drugs
2. Psychiatric drugs
3. Other drugs
4. Synthetic opioids: Levomethadyl 
5. Opium
Potassium Channel ... Organophosphates #Potassium ... #Medications #Differential ... #Diagnosis #Pharmacology
Ventilator Alarms
Increased Rate - Patient is tiring on a weaning mode or experiencing pain/anxiety
 - Reassess
cuff leak, check pilot ... leaks & tighten all ... cuff leak, check pilot ... leaks & tighten all ... MechanicalVentilation #Nursing #Differential
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... • NSAIDs • ACE ... • Recent IV potassium ... #hyperkalemia #differential ... diagnosis #causes #potassium
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
) MECHANISM: Potassium ... patiromer) is a potassium ... ACE inhibitors, ... Veltassa #Patiromer #Potassium ... #Hyperkalemia #Pharmacology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
the basis of the potassium-to-creatinine ... • Low Urine Cl ... • High Urine Cl ... hypokalemia #urine #potassium ... #differential #
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... • Inhibit Na+ Cl ... Piretanide Potassium ... #Diuretics #Pharmacology