23 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... Metolazone) 5) Potassium-sparing ... diuretics (e.g. ... #pharmacology # ... nephrology #medications
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... Chlorthalidone POTASSIUM-SPARING ... Tolvaptan #Diuretics ... #Medications #Pharmacology ... summary #table #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... • Inhibit Na+ Cl ... Piretanide Potassium ... #Pharmacology # ... nephrology #conversion
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... minutes) Decrease potassium ... Fluids Shift potassium ... function) - Loop diuretic ... #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypertensive: • High Al ... aldosteronism • High Al ... >20 mEq/24 h - Diuretics ... Diagnosis #Algorithm #nephrology ... #causes #low #potassium
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... Inhibitors of Na+K+2Cl ... Symport (Loop Diuretics ... Tolvaptan) • Treatment ... #Nephrology #Pharmacology
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
with excreting potassium ... Antagonists), all ... diuretic, which ... , just like all ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
the basis of the potassium-to-creatinine ... - Loop diuretics ... , Thiazide diuretics ... hypokalemia #urine #potassium ... algorithm #diagnosis #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Stabilization Treatments ... Ca-gluconate or 1g CaCl ... Redistribution Treatments ... Elimination Treatments ... #potassium #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Kidney loss of Cl ... loop or thiazide diuretics ... pressure: Active diuretic ... of sodium and potassium ... urine #Algorithm #nephrology