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differential anemia obstetrics pregnancy causes cold disease hepatitis hepatology liver table thrombocytopenia ttphus workup agglutinin autoimmune classification enlarged extravascular hemolysis
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Lymphoproliferative disorder ... , Autoimmune disorder ... Mycoplasma, HIV, EBV ... #Anemia #hematology ... #diagnosis #comparison
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
of Pregnancy (AFLP ... (Hemolysis, Elevated ... #AFLP #obstetrics ... #hematology #diagnosis ... #table #comparison
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... coagulation (DIC) - HELLP ... lymphoproliferative disorders ... #differential #diagnosis ... #hematology #anemia
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
coagulation defects. 1) HELLP ... (Hemolysis, Elevated ... #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... thrombocytopenia - DIC, TTP, HELLP ... Consider RBC membrane disorder ... #hematology #testing
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Algorithm Infectious ... Bacterial • Viral (EBV ... Myeloproliferative disorders ... Serum Sickness Hemolytic ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... → Refer to hematology ... workup, including BM ... blood loss, Acute hemolysis ... #Algorithm #hematology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
, no necrosis HELLP ... Syndrome (Hemolysis ... obstetrics #hepatitis #comparison ... #differential #diagnosis ... #icp #HELLP #AFLP
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... HBV, HCV, HEV, EBV ... • Pregnancy: HELLP ... #algorithm #hepatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... infection, autoimmune disorder ... Diagnosis: • hemolytic ... - Mycoplasma, EBV ... #anemia #hematology
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