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Causes of Aplastic Anemia

#Aplastic #Anemia #Causes #Pathophysiology #Pathology #Treatment #Management #Differential
Causes of Aplastic Anemia ... #Aplastic #Anemia ... #Causes #Pathophysiology ... #Pathology #Treatment ... #Management #Differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... Thalassemia • ACD ... Non-hemolytic: ACD ... , Aplastic anemia ... MCV #Algorithm #Differential
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
• chronic anæmia ... - Sickle cell anemia ... Dissociation #Curve #Pathophysiology ... #Right #Shift #Differential
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
Hyperuricemia - Differential ... Myeloid Leukemia (AML ... - Hemolytic Anemia ... drugs • ACE ... Hyperuricemia #Differential
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... • Blood smear: Differential ... Autoimmune #Hemolytic #Anemia ... diagnosis #management #treatment
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... hospitalization and treatment ... In addition to APL ... ) t(8;21), AML with ... Rods #AuerRods #APL
High Output Heart Failure - Pathophysiology and Differential Diagnosis
Obesity - Systemic Vasodilation, Vasoactive Adipokines
Arteriovenous Fistula -
Heart Failure - Pathophysiology ... and Differential ... Metabolism Severe Anemia ... HeartFailure #CHF #Pathophysiology ... #Differential #
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... #hyperkalemia #differential ... #diagnosis #pathophysiology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Acute • Myloid (AML ... • Lymphoid (ALL ... Pelger-Huet, Macrocytic anemia ... hematology #Markers #Differential
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Diagnostic Algorithm Pathophysiology ... : - Catch-all term ... range of potential pathophysiologic ... - Pathophysiology ... Targetoid #Algorithm #Differential