39 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... , AML, NHL → AKI ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... #TumorLysis #Syndrome ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... leukapheresis - TLS ... : • Pathophysiology ... #TLS #diagnosis
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... Culprits: ALL, ... #Tumor #Lysis #Syndrome ... #TLS #Pathophysiology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... leukemia (both ALL ... and AML) and solid ... #Tumor #Lysis #Syndrome ... #TLS #oncology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... differential #diagnosis #pathophysiology ... #pharmacology #
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
Hydroxyurea - Pathophysiology ... vs. 1) • Fewer ACS ... Benefits #SickleCell #pathophysiology ... #pharmacology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
• Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology #
Atopic Dermatitis - Topical Treatment Options 
First Line: Topical Corticosteroids 
  - High Potency: Betamethasone
After non-pharmacologic ... Remember that all ... TCS are not equal ... Aside from TCS, ... #Medications #Pharmacology