21 results
diagnosis differential causes nephrology management potassium algorithm hypokalemia tls oncology classification medications rhabdomyolysis tumor tumorlysis uricacid acute aki cancer cardiology
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... Syndrome (TLS) ... Tumor Cell Lysis ... -> Allantoin (High ... Hypocalcemia • Hyperkalemia
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Intracellular Shift ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... cytotoxic therapies in high-burden ... ) occur in high ... malignancies Treatments ... #Syndrome #TLS
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... organ damage • Treatment ... Spontaneous if high ... hydration - Hyperkalemia ... treatment (no calcium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Intracellular Shift ... release due to cell lysis ... reaction - Tumor lysis ... syndrome - Rhabdomyolysis
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Rhabdomyolysis • Tumor lysis ... syndrome • Metabolic ... glycosides • High ... MCW_Nephrology #HyperKalemia
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... and Treatment of ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm Transcellular Shift - Appropriate renal excretion (GFR,
Causes of Hyperkalemia ... Intercellular Shift ... Transcellular Shift ... Tumor Lysis Syndrome ... • Digoxin #Hyperkalemia
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... creatinine) • Cell shift ... mmol creatinine) High ... Low-normal EABV, High ... #hypokalemia
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
associated with hypokalemia ... hypomagnesemia Hypokalemia ... - Shift from extracellular ... - Insulin (high ... renal Fanconi syndrome
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