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hematology differential erythematosus systemic treatment classification druginduced product reactions summary algorithm anemia aplastic approach arthritis cerebritis cns comparison complications diffuse
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Discontinuation of causal ... Manifestations: Malar ... #table #rheumatology ... #diagnosis #management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... Insufficient blood ... #rheumatology # ... pharmacology #levels #lupus ... #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... thrombosis and/or blood-brain ... CNS #neurology #rheumatology ... #management #treatment
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... • Systemic Lupus ... • Insect Bites ... #Hematology #Oncology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... inflammation on skin -> Malar ... endothelium) & Decr blood ... pathophysiology #diagnosis
SOAP BRAIN MD Mnemonic for Systemic Lupus Erythematosus (SLE) S - Serositis (Pleuritis, Pericarditis) O - Oral Ulcers A
Erythematosus (SLE ... Photosensitivity B - Blood ... Symptoms M - Malar ... #Rheumatology # ... Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... Leishmaniosis, malaria ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... #management #treatment
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... -> AML: Blast crises ... response to mosquito bites ... #Leukemia #Hematology ... #Oncology #Diagnosis
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
to Joint Pain - Diagnostic ... spondyloarthropathies, lupus ... Like in this case ... Chronic = RA, SLE ... Joint #Pain #MSK #rheumatology
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