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differential management sle erythematosus table dermatology systemic arthritis vasculitis algorithm pain treatment blood classification disease msk oncology reactions syndrome workup
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
M DAMN SHARP - Lupus ... Anti-phospholipid) M Malar ... Antinuclear Antibody (ANA ... Pleuritis) H Hematologic ... erythematosus #rheumatology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Anti-retrovirals, Gemcitabine Lupus ... • +ANA, +Anti-Smith ... uncommon 5-15% of lupus ... #differential #diagnosis ... #comparison #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... B19 infection Malar ... lesions • Discoid lupus ... #differential #diagnosis ... #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... spondyloarthropathies, lupus ... Like in this case ... #rheumatology # ... #differential #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Manifestations: Malar ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
in at least 2 joints ... pericarditis • Hematologic ... low C4, Low C3 and ... Erythematosus #diagnosis ... #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... ) Inflammatory joint ... many differential diagnoses ... #diagnosis #sle ... erythematosus #rheumatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... INVOLVING 2 OR MORE JOINTS ... IMMUNOLOGIC CRITERIA - ANA ... hemolytic anemia #Diagnosis ... #Rheumatology #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #hematology #anemia
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