29 results
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... & NPSLE rare, Malar ... • Immunologic Workup ... comparison #table #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Arthritis 69% - Malar ... - Hemolytic anemia ... Auto-Antibodies: - ANA ... autoantibodies #signs #symptoms ... #differential #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... Manifestations: Malar ... • Immunologic Workup ... : - ANA > ... Management #Summary #rheumatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
Erythematosus Clinical ... Criteria CLINICAL ... NEUROLOGIC - HEMOLYTIC ANEMIA ... IMMUNOLOGIC CRITERIA - ANA ... #Diagnosis #Rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... • Infections: Malaria ... disease, Copper and ... differential #diagnosis #hematology ... #anemia
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... of Systemic Lupus ... ) Blood (75%): Anemia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... • CNS symptoms ... • Travel to malaria–endemic ... node biopsy • Clinical ... values supporting hematologic
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
should be interpreted ... context of other symptoms ... likely it will be clinically ... , Drug-induced Lupus ... #patterns #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... : • Symptoms limited ... Erythematosus #Diagnosis #Rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Workup History ... pylori test (GI symptoms ... changes), high MCV anemia ... Diagnosis #Causes #Workup ... #hematology