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differential hematology causes hemolysis erythematosus extravascular intravascular sle systemic algorithm antibody autoantibodies autoimmune classification management mimickers monoclonal oncology paraproteinemias signs
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #hematology #anemia
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... AIHA • Anemia ... #Anemia #diagnosis ... #management #treatment ... #rheumatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... Infections • Malaria ... anemia • ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Hypersplenism • AIHA ... Bartonella, Babesia, Malaria ... #Diagnosis #causes
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Infections/toxins: Malaria ... Defects: Sickle cell anemia ... #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Arthritis 69% - Malar ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... #differential #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Coagulopathy) SMZL: • AIHA ... • Coombs (-) hemolytic ... anemia due to cold ... IgG • Lupus anticoagulant ... #Differential #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Photosensitivity • Malar ... Hematologic: • AIHA ... lymphopenia, low PLT • Anemia ... #Rheumatology
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